methyl methacrylate health effects

Toxicological Review (PDF) (83 pp, 275 K) IRIS Summary (PDF) (31 pp, 204 K) Key IRIS Values; Other EPA Information; . Methyl methacrylate is irritating to the skin, eyes, and mucous membranes in humans. I. When exposed to MMA in the work environment, surgical staff have been reported to suffer from hypersensitivity, asthmatic reactions, local neurological symptoms, irritations and local dermatological reactions. METHYL METHACRYLATE (MMA) Acrylic appliances produced by professional dental labs undergo curing processes, so . The purity of commercial methyl methacrylate is typically 99.9%. ACUTE HEALTH EFFECTS SWALLOWED! MMA can cause allergic skin reactions, according to the Occupational Safety and Health Administration 1. 224 Acta Chim. The correct terminology is Methyl Methacrylate - MMA for short. Concerns have been raised regarding its potential toxicity in dental use, both for the patient and also in the workplace. Methyl methacrylate | C5H8O2 | CID 6658 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities . Canada (1993) review to assess the potential effects on human health of indirect exposure to methyl methac-.. Arch Occup Environ Health 65: 227 - 232. Methyl methacrylate (MMA) is an organic compound with the formula CH 2 =C(CH 3)COOCH 3. . Share sensitive information only on official, secure websites. Additionally, it may induce narcotic effects such as drowsiness or dizziness. An experimental study. Methyl methacrylate (MMA), a widely used monomer in dentistry and medicine, has been reported to cause abnormalities or lesions in several organs . 2005, 52, 224-229 Scientic Paper Copolymerization of Methyl Methacrylate and Dodecyl Methacrylate Initiated by Bifunctional Peroxide Ljubica Tomaek, Ante Juki, and Zvonimir Janovi* Faculty of Chemical Engineering and Technology, University of Zagreb, Maruliev trg 19, P.O. As the nation's health protection agency, CDC saves lives and protects people from health, safety, and security threats. Free radicals, antioxidants, and human disease; curios- health effects in workers occupationall y exposed to methylmethacrylate . Respiratory effects have been reported in humans following acute (short-term) and chronic (long-term) inhalation exposures. Int ity, cause, or consequence . is a natural antibacterial agent that is produced by Lactococcus lactis and has been approved by the . It is an irritant to the eyes and can cause redness and pain. Methyl Methacrylate may affect the liver and kidneys. Measurement of time-weighted average (TWA) intensity of the vapor exposure was successfully conducted with a diffusive sampler with activated carbon cloth as an adsorbent . Health Effects: Methyl Methacrylate may damage the nervous system causing numbness, "pins and needles," and/or weakness in the hands and feet. Chronic effects are sought for in past symptomatology, blood pressure, respiratory function testing, hemoglobin and white blood count, urinalysis, and blood chemistry. Identified uses : Methyl methacrylate is used in the manufacture of methacrylate resins and plastics (e.g., Plexiglas). However, the International Agency for Research on Cancer (IARC) said it was . Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment. Sci. 17. Concerns have been raised regarding its potential toxicity in dental use, both for the patient and also in the workplace. High exposure can cause dizziness, irritability, difficulty with concentration and . METHYL METHACRYLATE: ICSC: 0300 (November 2003) Methacrylic acid methyl ester Methyl 2-methylpropenoate: CAS #: 80-62-6: UN #: 1247 EC Number: 201-297-1 ACUTE HAZARDS . Frequent users of products made from acrylic resin are subject to more complex health effects, especially those people i.e. MMA can cause allergic skin reactions, according to the Occupational Safety and Health Administration 1. (2) Uses Methyl methacrylate is used in the manufacture of methacrylate resins and plastics (e.g., Plexiglas). Allergic response Chest tightness, coughing, wheezing, shortness of breath, reduced peak respiratory flow Asthma attacks - cases of occupational asthma linked to methyl methacrylate have been reported A product such as hairspray that contains MMA can also cause itching, redness and tearing of the eyes. Methyl Methacrylate is a colorless liquid with an acrid fruity odor. Summary of HEAST Information on-Line: Subchronic and Chronic Toxicity: Chronic [RfD]: IRIS: Subchronic [RfD]: on-Line : Chronic [RfC]: . It is hydroxylated to a primary alcohol, after which is oxidized to an aldehyde. It does list concerns that it can be a carcinogen, cause allergic reactions, immunotoxicity, and organ system toxicity. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment . Toxicity of methyl methacrylate in dentistry. What are the health effects of exposure to methacrylates? Low quantities of MMA are readily metabolized via the lipolytic pathways. These are used in construction, automotive, consumer products and in making signs. . Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora . The more often you use these products, the greater the risk will be. US Department of Health and Human Services CfDCaP. An RfD may also be derived for the noncarclno- genlc health effects of compounds that are also carcinogenic. Environ. Box 177, HR-10000 Zagreb, Croatia E-mail: zjanov@fkit.hr Received 19-05-2005 . 8 The reported half-life of this process is 15 hours (hydroxyl) and 1 day (ozone), respectively. Environmental issues and health hazards. The concentrations of . The MMA monomer is a colorless, pungent liquid metabolized to methacrylic acid, with described toxicities to various tissues [ 3, 4 ]. It has a relatively high vapour pressure (4000 Pa at 20C ), moderate water solubility (15 800 mg/L), and a low log octanol:water partition coefficient (K ow ) (1.38) (ACGIH, 1986; Dean, 1985; Tanii and Hashimoto, 1982). Data suggest that effects may occur in the higher concentration exposure groups with regard to serum glucose, and blood urea nitrogen, cholesterol, albumin, and total bilirubin . Methyl methacrylate (MMA) is a bonding agent used in artificial nail products. Patients of aesthetics must always be warned not to treat . The objective is to develop smart polymer nanocomposites using spray-coated graphene nanoplatelet (GNP)-doped polymethyl methacrylate on the surface of aluminium beams (2024-T351) and monitor gauge . View Record in Scopus Google Scholar Repeated exposure of animals by inhalation to levels at or above the occupational exposure level produces adverse effects on the nasal epithelium (levels of 100 and 400 ppm). Corts, C. et al. The effects of methyl methacrylate monomer on testosterone level in male rats. The empirical formula for MMA is C 5H 8O 2, and the CAS registry number is 80-62-6. . methyl methacrylate monomer monomeric methyl monomeric color Prior art date 1940-11-13 Legal status (The legal status is an assumption and is not a legal conclusion. Chronic Cardiovascular effects: Palpitations, chest discomfort, etc. Methyl methacrylate is expected to volatilize from dry soil surfaces . Methyl methacrylate (MMA) is often used in the healthcare setting as the main constituent in bone cement for fixation of orthopaedic implants as well as restorative and prosthetic resins in dentistry [ 1, 2 ]. The adverse effects of this monomer are well described in the literature. Chemicals Physical Properties Health Effects Chemical Properties Welfare Effects Methyl Methacrylate . MMA is not a human cancer causing agent and it does not absorb through the nail plate to affect the health of clients or nail technicians. In regards to their effects on human health, the CDC comments, "Human health effects from exposure to low levels of phthalates are unknown. OSHA PEL: TWA 100 ppm (410 mg/m3) NIOSH REL: TWA 100 ppm (410 mg/m3) Health effects. *Methyl Methacrylatemay damage the nervous system causing numbness, "pins and needles," and/or weakness in the hands and feet. 8-10 Interestingly, the majority (90%) of surgeons who left the room stated that they . (1,4,7,11) The principal uses of methyl methacrylate are: cast sheet and other grades (advertising signs and displays, Ingredients linked to developmental and reproductive toxicity, a broad class of health effects that range from infertility and reproductive organ cancers to birth defects . Safety Measures/Side Effects: Poly (methyl methacrylate) (PMMA) is considered safe, and is rated as a low hazard ingredient by the Cosmetics Database. Individual Animal Data. Structure of methyl methacrylate. Female Individual Animal Survival Data. Download Citation | Transparent Polymer Blends of Poly(methyl methacrylate) and Poly(propylene glycol) | Polymer blends, obtained by polymerization of methyl methacrylate in the presence of poly . Methyl methacrylate (MMA) is a monomer, commonly used in neurosurgery, orthopedic surgery, and in dental clinics. Health, 65 (1993), pp. Methyl methacrylate (C 5 H 8 0 2) is a colourless, volatile liquid with an acrid, fruity odour. Cancer . Int. Methacrylates are generally of low toxicity, have not been found to damage reproduction or harm the unborn child, and studies in workers exposed to methacrylates for more than 30 years indicate that there is no increased risk of developing cancer due to occupational exposure. This database provides information on chemical . Experimental and clinical studies have documented that monomers may cause a wide range of adverse health effects such as irritation to skin, eyes, and mucous membranes, allergic dermatitis, stomatitis, asthma, neuropathy, disturbances of the central nervous system, liver toxicity . Biological monitoring and possible health effects in workers occupationally exposed to methyl methacrylate. . Previous studies have highlighted the adverse effects and toxicity of PMMA (poly (methyl methacrylate))-based dental materials, at both the tissue and cellular levels, although systemic toxicity . Monitoring by means of blood and urine analysis for methanol was successfully applied in 32 male workers who were exposed to methyl methacrylate (MMA) monomer at 6 ppm as a geometric mean and at 112 ppm as the maximum. California Occupational Safety & Health Standards Board: Initial and Final Statement of Reasons. using the same exposure, protocol assessed the effects of methyl methacrylate on terminal body weight, tissue weights (adrenals, epldldymal and popliteal fat pads), blood chemistry and metabolic parameters. (methyl methacrylate) (PMMA) are commonly used for minor . Methyl methacrylate (MMA), a colourless liquid, is the most commonly used acrylate for forming dental prostheses . EPA: Integrated Risk Information System -Methyl Methacrylate (CASRN 80-62-6). * Volatilization of methyl methacrylate from moist soil surfaces is expected to be an important fate process (SRC) given an estimated Henry's Law constant of 3.2X10-4 atm-cu m/mole (SRC), based upon its vapor pressure, 38.5 mm Hg (4), and water solubility, 1.57X10+4 mg/L (5). Methyl methacrylate CASRN 80-62-6 | DTXSID2020844. Occ. Respiratory Tightness in chest, wheezing, cough, occupational asthma (due to particles in air) and shortness of breath. 2PROPENOIC ACID, 2METHYL, METHYL ESTER and METHYL METHACRYLATE. This is because of the lack of corroborating animal or . Furthermore, this substance can cause serious eye damage. Used to manufacture plastics, construction chemicals, and textile applications; Exposure Limits. Other health side effects of acute exposure to methyl methacrylate are: irritation to eyes, nose, and throat, dizziness, nausea, vomiting, and hypotension. . 1, 11-15, 2008. Environ. July 6, 2006. The U.S. Department of Energy's Office of Scientific and Technical Information Data on the effects of a single exposure to MMA is unavailable but studies indicate that in end user occupations like that of the operating nurse, . *Methyl Methacrylatemay cause a skin allergy. Poly(methyl methacrylate) sc-255435 Hazard Alert Code Key: EXTREME HIGH MODERATE LOW RISK EMERGENCY OVERVIEW May cause SENSITIZATION by inhalation and skin contact. Health Effects Methyl methacrylate is a hazardous chemical which should be handled with care. An RfD may also be derived for the noncarclno- genlc health effects of compounds that are also carcinogenic. * Methyl Methacrylatemay affect the liver and kidneys. Chronic Health Hazard Assessments for Noncarcinogenic Effects . Slov. Biological monitoring and possible health effects in workers occupationally exposed to methylmethacrylate. Skin, eye, and nasal irritant; Additional Resources . The material has NOT been classified as "harmful by ingestion". Methacrylate (7) and Health and Environmental Effects Profile for Methyl Methacrylate. METHYL METHACRYLATE First draft prepared by Ms W. Dormer, Ms R. Gomes, and Ms M.E. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.) TR-314 Toxicology and Carcinogenesis Studies of Methyl Methacrylate (CASRN 80-62-6) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) [Abstract] Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Int Arch Occup Environ Health 65: . Methyl methacrylate CASRN 80-62-6 | DTXSID2020844. ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Methyl Methacrylate. Yuji Nishiwaki, Takehito Saitoh, Toru Takebayashi, Shigeru Tanaka, Norihito Etoh, Yoko Eitaki, . Male Individual Animal Pathology Data Neoplastic. 227-232. Occupational health guidelines for methyl methacrylate recommend medical surveillance of employees with COAD, skin, kidney and liver disease, as exposures to MMA vapour may exacerbate symptoms. Available online: https://pubmed.ncbi.nlm.nih.gov/19534085/ Fakhouri J, Sarkis R, Chababi-Atallah M, Aftimos G. Toxic effects of methyl methacrylate monomer on male genital tissues. using the same exposure, protocol assessed the effects of methyl methacrylate on terminal body weight, tissue weights (adrenals, epldldymal and popliteal fat pads), blood chemistry and metabolic parameters. Biological monitoring and possible 16. Cohort and cross-sectional worker studies reported irritation of eyes, nose, and upper respiratory tract associated with short-term peaks exposures, but little evidence for respiratory sensitization or asthma. Expired - Lifetime Application number US365463A Inventor Barnard M Marks Methyl methacrylate-potassium acrylate copolymer | C8H11KO4 | CID 23693564 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. . Nasal symptoms Reduced lung function Methyl methacrylate monomer Methyl methylacrylate Methyl-2-methyl-2-propenoate . However the use of MMA has been associated with adverse health effects, and MMA-based acrylic nails will be tough, inflexible and difficult to remove. Some types of phthalates have affected the reproductive system of laboratory animals. . A product such as hairspray that contains MMA can also cause itching, redness and tearing of the eyes. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment . Health and environmental effects profile for Methyl Methacrylate. 1) Methyl methacrylate is metabolized to methacrylic acid (via coenzyme A) which is a normal intermediate in the Krebs cycle. MMA can affect the nervous system, causing symptoms similar to drunkenness, but most people will experience irritation first. . In terms of the acute toxicity of methyl methacrylate, the LD 50 is 7-10 g/kg (oral, rat). See annual publication for most recent information. Experimental and clinical studies have documented that monomers may cause a wide range of adverse health effects such as irritation to skin, eyes, and mucous membranes, allergic dermatitis, stomatitis, asthma, neuropathy, disturbances of the central nervous system, liver toxicity, and fertility disturbances. J Med. Methyl methacrylate (MMA), a monomer of acrylic resin, has a wide variety of dental, medical and industrial applications. Methyl methacrylate Revision Date 24-Dec-2021 Upper 12.5% Lower 2.1% Vapor Pressure 40 mbar @ 20 C Vapor Density 3.5 (Air = 1.0) Specific Gravity 0.930 Solubility No information available Partition coefficient; n-octanol/water No data available Autoignition Temperature 430 C / 806 F Decomposition Temperature No information available Viscosity 0.6 mPa s at 20 C The synonyms for MMA listed in MEDLARS (1986), are as follows: metakrylan metylu; methacrylate de methyle; methacrylic acid methyl ester (8CI); methacrylsaeuremethyl ester; 1, 7 PMMA vapor released into the air is broken down by exposure to hydroxyl radicals and ozone. This output contributes to the following UN Sustainable Development Goals (SDGs) Flexural strength values, antimicrobial effects, anti-biofilm potential, and anti-metabolic activity against S. mutans and C. albicans were assessed at different time intervals. Found inside - Page 75Methyl methacrylate has potential health effects that have not been proven . . HOW TO FIND OUT IF YOU ARE WORKING WITH METHYL METHACRYLATE Methyl methacrylate has the potential to induce skin sensitisation in susceptible individuals. Poly(methyl methacrylate) (PMMA) belongs to a group of materials called engineering plastics.It is a transparent thermoplastic.PMMA is also known as acrylic, acrylic glass, as well as by the trade names and brands Crylux, Plexiglas, Acrylite, Astariglas, Lucite, Perclax, and Perspex, among several others ().This plastic is often used in sheet form as a lightweight or shatter-resistant . Methyl methacrylate (MMA), a monomer of acrylic resin, has a wide variety of dental, medical and industrial applications. Skin, eye and mucous membrane irritation. This database provides links to health effects information and registration status for pesticides. Lower methyl methacrylate cocentrations were consistently measured at the syringe tip end, suggesting loss resulting from methyl methacrylate's volatility. If allergy develops, very low future exposure can cause itching and a skin rash. Posted May 3, . What are the health risks? Liban, vol. Based on the results of the health effects research presented in this report, and the ambient concentration estimates, it appears that methyl methacrylate as an air pollutant does not pose a threat to the health of the general population. Scientific PapersToxicity of methyl methacrylate in dentistry. Methyl methacrylate has been determined to be a systemic toxicant. It is present in nail preparations used in and beauty salons throughout Australia. Objectives: The Effects of Methyl Methacrylate on Nasal Cavity, Lung, and Antioxidant System (An Experimental Inhalation Study) Created Date: 5/22/2002 12:42:31 PM . POTENTIAL HEALTH EFFECTS ! Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments. The main purpose is to monitor the sensitivity of graphene nanoplatelet (GNP)-doped polymethyl methacrylate (PMMA) sensor under temperature-loaded aluminium 2024-T351 under mechanical loading. . An Acceptable Daily Intake (ADI), defined as the amount of a chemical to which humans can be exposed on a daily basis over an extended period of time (usually a lifetime) without suffering a deleterious effect, for methyl methacrylate is 5.3 mg/day for oral exposure. Methyl Methacrylate may damage the developing fetus in pregnancy. I.A. Methyl Methacrylate CAS: 000080-62-6 . . . EXPOSURE & HEALTH EFFECTS; Routes of exposure The substance can be absorbed into the body by inhalation, through the skin and by ingestion. forty-six male Sprague . Scientific PapersToxicity of methyl methacrylate in dentistry. The integrity of latex gloves may also be compromised following exposure to MMA during surgical procedures. If inhaled, methyl methacrylate can cause respiratory irritation and labored breathing, and may progress into asthmatic symptoms. Neurological Numbness, pain, and pallor (whitening of fingers), headache, lack of concentration, and lethargy. Sources/Uses. Summary of HEAST Information on-Line: Subchronic and Chronic Toxicity: Chronic [RfD]: IRIS: Subchronic [RfD]: on-Line : Chronic [RfC]: . An allergic response to dermal exposure may develop. Halliwell B (1994). Methyl methacrylate is used in the manufacture of resins and plastics. Repeated exposure to high levels produces adverse effects on the heart, lungs, liver and kidneys. 56, no. Taniuchi T, Moon CS, Ikeda M (1993). Public Health, Environmental and Occupational Health; UN SDGs. There are also recorded cases of skin irritations attributed to acute contact with the substance. Health Effects Laboratory Division, Allergy and Clinical Immunology Branch, National Institute for Occupational Safety and Health (NIOSH), Morgantown, WV 26505, USA . Arch. Dental technicians and dentists who work with MMA have been found to . Figure 1. Nanoplastics as a potential environmental health factor: effects of polystyrene nanoparticles on human intestinal epithelial Caco-2 cells. Methyl methacrylate methyl methacrylate. Evaluation of the Chronic Toxicity and Carcinogenicity of Methyl Methacrylate (80-62-6) in Male B6C3F1 Mice via Whole Body Respiratory Exposure. Finally, it is converted to pyruvic acid. Cross-sectional study of health effects of methyl methacrylate monomer among dental laboratory technicians.