inbred rat strains

General studies, Immunology, Only approved mouse strain for use in the Local Lymph Node Assay, a refined alternative research method for evaluating the allergic contact dermatitis potential of chemicals and compounds. 132 rat inbred strains. Search over 14 million words and phrases in more than 510 language pairs. Created by. This Paper. (PDF) The third region on rat chromosome 3 identified in the current Table S5 Cholesterol concentration in individual lipo- study affecting cholesterol and triacylglycerol concentrations in protein fractions l in the PXO recombinant inbred strain LDL harbors three genes with non-synonymous mutations in SHR panel and its progenitor strains, BXH2 . In contrast with previous listings, an. Both sets of information were provided by Dr. Michael FW Festing (MRC Toxicology Unit) and were converted for Web presentation by the Mouse Genome Informatics Group at The Jackson Laboratory. The first listing of inbred strains of rats was by Billingham and Silvers (1959). DNA fingerprinting method was applied to identify inbred strains of laboratory rats. An inbred, wild caught strain had 6.2 cm long tails. Translation for: 'rats, inbred strains' in English->Armenian dictionary. Anim. Wild rat-derived SNP characteristics. This study examined the effects of cocaine or amphetamine on locomotor activity in rats from the ACI, F344, LEW and NBR inbred strains. The tree was calculated through maximum parsimony analysis implemented in PAUP 4.0b10. Nomenclature for rat strains A capital letter or letters in Roman type designates inbred strains eg. What our customers say: "The MRC Mary Lyon Centre located at MRC Harwell uses Taconic's inbred mouse lines (specifically C57BL . Vaginal distension (VD) in outbred rats has been shown to decrease urethral resistance, as well as increase the expression of the stem cellhoming chemokine, monocyte chemotactic factor 3 (MCP3), but not stromal derived factor 1 (SDF1). The consomic rats and the data are available from the PhysGen Programs There is now considerable background information on strain characteristics, including life-span, spontaneous diseases and response to chemicals. Origin: Inbreeding of the Lewis rat is begun by Dr. Margaret Lewis from a Wistar stock. After 40 generations of . . "Many of the most widely used inbred strains of rats were also developed during this period, several of them by Curtis and Dunning at the Columbia University Institute for Cancer Research. Terms in this set (15) ACI. Test. Many targeted mutations ( e.g., "knockouts") are maintained on a mixture of C57BL/6 and a particular 129 strain. The verification of 746 candidate SNPs by amplicon-based resequencing in 36 inbred rat strains and three wild-derived samples (wild 1, 2, and 3) revealed 960 polymorphisms, consisting of 90 indels, seven 2-bp substitutions, one 3-bp substitution, one 5-bp substitution, and 861 SNPs, of which only one was tri-allelic. inbred rat strain address bn rat dahl rat vasodilator phenotype ss-13 bn rat l diet vascular relaxation mechanism 40-45 mm hg consomic rat impaired renin-angiotensin system normal ra regulation dahl salt restored vasodilation ang ii vascular relaxation high salt diet brown norway ss-16 bn rat renin gene 10-6 mol dahl genetic background po2 . : A group of strains derived usually from two progenitor strains wherein the genomic structure of each is scrambled with the other by recombination and then alleles are fixed by inbreeding. Inbred Lewis (LEW) and Fischer 344 (F344) rats are differentially sensitive to drugs of abuse, making them useful for studying addiction-related neural mechanisms. 5. Download Download PDF. 10 inbred strains and 2 wild rats, compare amounts and patterns of genetic diversity, and discover novel variants among strains, thereby providing a resource for investiga-tors using these strains of rats. Wistar, Fisher, and Sprague Dawley, and their hundreds of internal divisions, are examples of rat strains. Question: em Solving 9. Google Scholar Eight inbred strains ( n 6 rats/strain) were selected for the study: the pigmented ACI, BN and COP strains and the albino F344, LEW, SHR, WAG and WKY . Genetic markers in the rat: importance of inbred strains and Donryu rat. The properties of inbred and outbred mice and rats are briefly reviewed, and it is concluded that, with some exceptions, there is a strong case for using inbred strains in most controlled experiments. Find rat and mouse models for research applications, including toxicology, pharmacology, immunology, oncology, & various other disease related research disciplines. Twenty-four Nobel prizes since 1960 which depended on the use of inbred strains. Phylogenetics of rat inbred strains Mamm Genome. The definition of inbred strains is valid first of all for rats and mice. TRADITIONALOUTBRED RATS Derived from theOkamoto-Aoki Strain Males exhibit average systolic blood pressures greater than 200 mm Hg by 3-4 months of age TheSHR is generally used for studies in hypertension and cardiovascular research Origin:TheSpontaneously Hypertensive outbred model was developed by NIH in 1966 fromWistar An inbred strain is one whose background can be defined and is named by the nomenclature conventions. METHODS Strains studied. inbred strain - Ontology Browser - Rat Genome Database . Identification of coding variants in each strain. 2003 Jan;14(1):61-4. doi: 10.1007/s00335-002-2204-5. Charles River stocks and strains are managed under the International Genetic Standardization (IGS) program, a unique program designed to manage the health and genetics of outbred and inbred strains on a global basis, ensuring that researchers worldwide have access to standardized models, regardless of the production location. Gravity. Abstract. Dose-dependent increases in locomotor activity were found for both drugs in all strains. I recently heard Howard Jacob (Medical College of Wisconsin) give a talk in which he showed that in Sprague Dawley rats ~one-third of the genome was fully inbred, and the average number of alleles for most loci was only 2 (whereas in a panel of 48 different inbred strains, the total available diversity averaged around 6 alleles/locus). The ACP genotyped 48 commonly used rat inbred strains by using over 4800 microsatellite markers with known genomic locations. There are now more than 150 rat strains and several hundred mouse strains (Beck et al. (www.jax.org); "Inbred Strains in Biomedical Research" (Michael Festing 1979) and "Origins and Characteristics of Inbred Strains of Mice . First, we identified homozygous coding variants in the 25 inbred rat strains. Autoregulation is routinely studied in the rat, of which there are many inbred strains. PLAY. Twelve different rat strains were studied in this project: August Copenhagen Irish (ACI/Eur); Fawn-hooded hyper- There are now extensive databases on mouse, and to a lesser extent rat genetics. The phylogenetic tree of 132 laboratory rat strains. Strains HO and AU, both Ag-B5, developed only minimal lesions, although AU rats had a high titer of circulating antibodies to thyroid antigens. The subjective value of rewards decreased as the delay to receipt increased for all . Genetic influences on survival time after severe hemorrhage in inbred rat strains. Strain: F344/NHsd Aged. Authors Michael A Thomas 1 , Chin-Fu Chen, Michael I Jensen-Seaman, Peter J Tonellato, Simon N Twigger. The first inbred strains of mice, rats, and guinea pigs were developed soon after the rediscovery of Mendel's laws of inheritance in 1900. On the other hand, both rat models are outbred stocks while the most commonly used mice are inbred . There are multiple strains of rat that are either selected or inbred as models of human pathology. four inbred rat strains. Here we have systematically studied the effects of genomic variants using two inbred rat strains, the spontaneously hypertensive rat (SHR/OlaIpcv) and a Brown Norway-derived strain, BN-Lx/Cub [3, 4]. . Joe Yeyo Aden. . In contrast, outbred stocks of rats such as Wistar and Sprague-Dawley are more widely used than inbred strains such as F344 and LEW. A list of inbred strains and their characteristics is maintained on the Jackson Laboratory web site. However, large potency and efficacy differences were found. By ligating the left internal and external carotid arteries, we caused a 90% decrease in left common carotid blood flow and a 50% increase in right (contralateral) common carotid flow. We refer to the strains as SHR and BN-Lx in this paper. To determine their genetic . Genetic profile of 12 inbred rat strains for 46 microsatellite loci selected as genetic monitoring markers. 14:173-177. 37 Full PDFs related to this paper. Many thousands of papers are published each year involving inbred mouse and rat strains. 2000). STUDY. To test the impact of genetic heterogeneity on cis- and trans-mediated mechanisms of gene expression regulation, we profiled the transcriptome of adipose tissue in 20 inbred congenic strains derived from diabetic Goto-Kakizaki (GK) rats and Brown-Norway (BN) controls, which contain well-defined blocks (1-183 Mb) of genetic polymorphisms, and in 123 genetically heterogeneous . Numerous flow-induced genes were revealed by this study, including a group of 8 genes that showed very strong flow induced expression conserved in both inbred strains.A group of 9 genes showed very strong flow induced expression with major differences between an aneurysm prone inbred rats and the aneurysm resistant inbred rats. The observations of the current study provide the first . Benefits jfrohlich23. genealogic study of inbred rat strains to better un-derstand relationships among strains and to provide a basis for the selection of rat strains for biomedical research. BN, PVG. This produces a situation where particular alleles can be examined on a collage of backgrounds composed of the genomes of the progenitors. All rat strains expressed strong rapid expulsion which resulted in the elimination of 88-98% of a challenge infection of muscle larvae. of the genome based on the inbred BN (Brown Norway) strain. We generated successive generations of a unique inbred rat strain, spontaneous trigeminal allodynia (STA) rats, previously reported to exhibit an episodic migraine-like behavioural phenotype. 1999). This analysis was performed in comparison with the reference genome, which is determined for Brown Norway rats (Gibbs et al. The advantage of using inbred animals for genetic studies is that essentially all . 2010).In each strain, the number of synonymous variants was . Background data on strain characteristics and mouse genetics accumulates rapidly. Outbred Rats: Strain Name: Common Name: ArcCrl:CD(SD)IGS: SD (Sprague Dawley) ArcCrl:WI. NON-GEM MOUSE AND RAT STOCKS AND STRAINS. Affiliation 1 . 1998 Michael FW Festing MRC Toxicology Unit, Hodgkin Building, University of Leicester, UK Similar research of mouse inbred strains has been signicant for studies of evolution and disease (Fitch and Atchley 1985; Beck et al. Download Download PDF. The microsatellite markers are spread relatively evenly across the rat genome and have been integrated into the rat radiation hybrid (RH) map (Steen et al. . Sprague-Dawley and Wistar are the two most frequently used rat models. 2009), and we have determined the protein coding genes and non-coding conserved sequences of some representative rat mutant strain + Learn. Four inbred strains differed greatly in their response to a standard inoculation of rat thyroid extract with complete Freund's adjuvant and pertussis vaccine. After 4 weeks of altered flow, there were significant interstrain differences with respect to the change in carotid outer diameter (OD), the METHODS. Hybrid panel The first listing of inbred strains of rats was by Billingham and Silvers (1959). ArcSim:LE: Wistar. Compared to mice, rats are bigger, generally more aggressive, and more resistant to various ailments. A short summary of this paper. Previous studies based on inbred mouse or rat strains have demonstrated the role of genetic factors in vascular remodeling and IMT (21, 25). Long Evans: Inbred Rats: Strain Name: Common Name: BN/RijHsdArc: BN (Brown Norway) . Phylogenetics of rat inbred strains. We show that both male and female STA rats display robust and sustained reductions in periorbital thresholds to cutaneous mechanical stimulation. 2004) (Table 1).The variants were then classified by applying ANNOVAR (Wang et al. Read Paper. However, large potency and efficacy differences were found. (Japanese) This is the fifth listing and has been substantially revised, although it is heavily dependent on previous listings (Festing and Staats, 1973). Behavioral effects of acute hexamethonium in rats chronically intoxicated with nicotine. Inbred Lewis and Fischer 344 rat strains differ not only in novelty- and amphetamine-induced behaviors, but also in dopamine transporter activity in vivo Abstract Inbred Lewis (LEW) and Fischer 344 (F344) rats are differentially sensitive to drugs of abuse, making them useful for studying addiction-related neural mechanisms. In 1958, at F31 to Silvers, who distributed this strain subsequently. We show that both male and female STA rats display robust and sustained reductions in periorbital thresholds to cutaneous mechanical stimulation. 2000).It was soon recognized that inbred strains were of value in many areas of research. Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity. The patterns were completely different among 15 rat strains examined, and the patterns of . Inbred Strains are produced by brother x sister mating for 20 or more consecutive generations, and individuals of the strain can be traced to a single ancestral pair at the 20th or subsequent generation. We discuss relevant characteristics of Brown Norway, Spontaneously hypertensive, Dahl, and Fawn-Hooded hypertensive rats and explore differences among these . Order today+1 800 793 7287. Analysis of "cold" plasma by furnace atomic absorption confirmed the presence of 10-15% of plasma copper in this peak. This is easily the most widely used general-purpose inbred rat strain, being particularly favoured for cancer research and toxicology. . The inbred strains will be referred to as S/JR and R/JR respectively. Inbred strains (also called inbred lines, or rarely for animals linear animals) . Inbred rat strains are produced by breeding related individuals, primarily brother by sister, for at least 20 consecutive generations. Plots of percent dose and 67Cu specific activity against time showed that copper followed a very specific pathway after binding to albumin and transcuprein . ACLAM Rat Inbred strain models. It was capable of donating copper to tumor cells in serum-free medium. Inbred Strains of Mice and Rats This page provides access to searchable, hypertext listings of inbred strains of mice and inbred strains of rats. 213 A selected, inbred rat strain had a tail measuring an average of 5.4 cm. Inbred rat strains may be useful in the development of physiological and biochemical models to study the genetic basis of ECM composition and IEL rupture in the rat aorta. Flashcards. Litters of newborn rats of five inbred strains (Fischer 344 [F344], Dark Agouti [DA], Sprague-Dawley [SD], Wistar-Furth [WF], Lewis [LEW]) and one outbred strain (Hooded Wistar [HW]) were maintained in room air or were exposed to alternating 24-hour cycles of hyperoxia (80% oxygen in air) and normoxia (21% oxygen in air) for 14 days and were killed for analysis, either immediately .